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KMID : 0361620070420050665
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Journal of the Korean Orthopaedic Association
2007 Volume.42 No. 5 p.665 ~ p.670
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The Relationships between Homocysteine, Folate, MTHER and TSER Polymorphism for Osteoporotic Compression Fracture in Postmenopausal Women
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Shin Dong-Eun
Cho Duck-Yun
Yoon Hyung-Ku
Kim Nam-Keun
Lee In-Seok
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Abstract
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Purpose: To analyze the relationships between homocysteine, folate, MTHFR and TSER polymorphism for postmenopausal women with osteoporotic compression fractures.
Materials and Methods: Forty-three postmenopausal compression fracture patients and as many normal controls were included. The plasma homocysteine and folate levels were measured using a FPIA (fluorescent polarizing immunoassay) kit. The MTHFR and TSER genotypes were amplified by PCR (polymerase chain reaction) and separated by RFLP (restriction fragment length polymorphism) in a 3.5% agarose gel.
Results: The plasma folate level was significantly lower in the postmenopausal women with osteoporotic compression fractures, particularly in the MTHFR 677CT and TSER 2R (??) genotypes. However, the plasma homocysteine level and MTHFR C677T polymorphism were similar to the control group.
Conclusion: A low folate level and the TSER 2R (??) genotype can be associated with osteoporotic compression fractures in postmenopausal women.
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KEYWORD
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Osteoporotic fracture, Homocysteine, Folate, MTHFR, TSER
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